Choosing a Skeletal Muscle Relaxant

Your doctor will write the number of refills authorized on your prescription. It isn’t known exactly how this drug works to relax your muscles. It may decrease the signals from your brain bupropion and flexeril that tell your muscles to spasm. Cyclobenzaprine also comes as an oral extended-release capsule. Adding plans allows you to compare formulary status to other drugs in the same class.

If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using Flexeril with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Flexeril is usually taken once daily for only 2 or 3 weeks. Do not use Flexeril if you have taken an MAO inhibitor in the past 14 days. If you notice other effects not listed above, contact your doctor or pharmacist.

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Using cannabis with cyclobenzaprine (Flexeril) may increase side effects such as dizziness, drowsiness, impaired thinking, confusion, and difficulty concentrating. Common side effects of cyclobenzaprine include headache, tiredness, dizziness, and dry mouth, and these adverse effects may increase in likelihood and severity by using cannabis. Skeletal muscle relaxants are often prescribed for musculoskeletal conditions including low back pain, neck pain, fibromyalgia, tension headaches, and myofascial pain syndrome. The goals of treatment include managing muscle pain and improving functional status so the patient can return to work or resume previous activities.

Overall rating for Cyclobenzaprine (Flexeril)

In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended.

  • The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms.
  • Yes, cyclobenzaprine can make you very sleepy and this side effect may get worse with higher doses.
  • Calls to our general hotline may be answered by private treatment providers.
  • In addition to inhibiting drug metabolism, ciprofloxacin could be involved in other types of drug interactions.
  • Take this medication by mouth with or without food as directed by your doctor.

Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

What should I know about storage and disposal of this medication?

These drugs may heighten the risk of side effects such as drowsiness, disorientation or lightheadedness, and mental impairment. All other drugs and substances mentioned here belong to the moderate classification of Cyclobenzaprine interactions. The combination of Cyclobenzaprine and alcohol, weed, or Ibuprofen may increase the risk of side effects, just not as much as Tramadol does. Before combining and taking any of them, one must assess the medical risks that come with them to ensure that necessary actions are taken as needed. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

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This is especially true if someone has been engaging in polydrug use with cyclobenzaprine and other substances. However, the half-life of immediate-release cyclobenzaprine is 18 hours on average, with a range of 8-37 hours. The extended-release form typically has a half-life of hours. Your dose will depend on the severity of your pain and the formulation of cyclobenzaprine you’re using. Don’t take this medicine for longer than three weeks without talking to your doctor.


Formulations include immediate-release and extended-release. If you are prescribed cyclobenzaprine, follow your healthcare provider’s directions for how to take it. Cyclobenzaprine is a drug prescribed to treat pain and discomfort. This page will go over its side effects, drug interactions, and treatment for misuse. Yes, cyclobenzaprine can make you very sleepy and this side effect may get worse with higher doses. Drowsiness is the most commonly reported side effect in studies, occurring in up to 38% (38 out of 100) of people.

Addiction Resource is an educational platform for sharing and disseminating information about addiction and substance abuse recovery centers. Addiction Resource is not a healthcare provider, nor does it claim to offer sound medical advice to anyone. Addiction Resource does not favor or support any specific recovery center, nor do we claim to ensure the quality, validity, or effectiveness of any particular treatment center. No one should assume the information provided on Addiction Resource as authoritative and should always defer to the advice and care provided by a medical doctor. Other drugs with moderate interactions like that of alcohol, weed, and Ibuprofen include Benadryl (Diphenhydramine), Gabapentin (Neurontin), Ambien (Zolpidem), and Xanax (Alprazolam).

Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Ciprofloxacin (Cipro®, Bayer), is one of the medications approved by the Food and Drug Administration for use after exposure to inhaled anthrax. It is among the top selling drugs in the United States and is used to treat a variety of other infections including urinary tract infections, skin infections, and pneumonia.

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